> The first human embryo splitting procedure was reported by a team of researchers including Robert Stillman and Jerry Hall from George Washington University in Washington, DC, in October 1993, at a joint meeting of the American Fertility Society and the Canadian Fertility and Andrology Society (Hall et al., 1993). > However, it was later found that the study did not possess the valid Institutional Review Board approval, and the authors were reprimanded and instructed to destroy their data (Fackelmann, 1994; Macklin, 1995).