*наркоманы *рационализм >Applying Hill’s criteria to the association between cannabis and schizophrenia, we find a modestly strong association, consistently demonstrated in a number of studies (Moore et al., 2007). Cannabis use almost always predates psychosis, is associated with an earlier age at onset (Donoghue et al., 2014; Myles et al., 2012b) and heavier and more potent cannabis users have an increased risk of developing psychosis (Di Forti et al., 2009) and do so at an earlier age than people smoking milder cannabis (Di Forti et al., 2014). There is evidence that the endocannabinoid system effects brain functions that are relevant to schizophrenia making the relationship plausibly causal (Bossong et al., 2014). Further, there is experimental evidence that cannabis can precipitate psychotic symptoms in healthy individuals (Martin-Santos et al., 2012). While none of these findings alone is conclusive, the weight of evidence is enough to convince most researchers that cannabis plays a causal role in some cases of schizophrenia.
