https://www.mailpile.is/blog/2014-09-13_Mailpile_Beta_Release.html
tldr: Mailpile looks like a local mail application with a webmail interface, intended to put a Gmail-like face on your mail without you having to actually go to gmail.com. However, Mailpile’s goal is much deeper than that—the company is building in seamless support for PGP encryption and key management, and Mailpile wants to enable its users to have fast and easy access to encrypted, secure communication.