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At first thought, heightened plasticity might seem to be a benefit—translating to faster learning and improved cognitive function; however, the excessive plasticity could also lead to high activity in all synapses and therefore reduce synaptic pruning. Impairments in synaptic pruning have in fact been associated with autistic spectrum disorders (Belmonte et al., 2004). The excessive connectivity leads to a heightened overall brain activation but the reduction in selectivity of activation is such that the signal-to-noise ratio is greatly lowered (Belmonte, 2000; Belmonte and Yurgelun-Todd, 2003). Thus, one can clearly see the potential dangers associated with unregulated plasticity, and how ampakines (which strengthen synapses and heighten plasticity by promoting dendritic spine growth) might lead to autism-like syndromes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026746/
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